In:
Military Medical and Pharmaceutical Journal of Serbia, National Library of Serbia, Vol. 74, No. 10 ( 2017), p. 940-946
Abstract:
The essence of rheumatoid arthritis (RA) pathogenesis is inflammation,
modification of immune system and cell damage. 5'-nucleotidase (5'-NT) and
adenosine deaminase (ADA) have a significant role in the process of
inflammation-caused tissue damage. The aim of the paper is to define
5'-nucleotidase and adenosine deaminase activity in serum of patients with
rheumatoid arthritis treated with Methotrexate and patients with rheumatoid
arthritis who have not been treated with Methotrexate, as well as to
determine correlation between the enzymes and disease activity. The research
included 160 patients suffering from rheumatoid arthritis, 60 of which have
not been treated with Methotrexate (age 56,8; 68,3% female) and 100 patients
treated with Methotrexate (age 59,8; 88% female), as well as 60 healthy
controls (age 58,8; 66,6% female). Patients suffering from chronic
inflammatory diseases, chronic respiratory, cardiac and kidney insufficiency,
severe acute diseases and other diseases which might modify inflammatory
response were not included in the research. There was no statistically
significant difference in 5'-NT values among groups. ADA values were
significantly different in all tested groups. Post Hoc analysis (Dunnett T3
test) showed that ADA activity in RA groups were significantly higher as
compared to control group (p〈0.001), and that ADA in RA group with MTX was
significantly smaller as compared to RA group without MTX (p〈0.001). There is
not significant correlation between the disease activity and activities of
tested enzymes. We concluded that adenosine deaminase activity was increased
in patients with rheumatoid arthritis, as well as that the application of
Methotrexate led to the decrease of this enzyme in the serum of patients with
rheumatoid arthritis. Activity of 5'-nucleotidase is not increased in
patients with rheumatoid arthritis and did not depend on Methotrexate
treatment. Serum adenosine deaminase and 5'-nucleotidase were not good
indicators of rheumatoid arthritis activity.
Type of Medium:
Online Resource
ISSN:
0042-8450
,
2406-0720
DOI:
10.2298/VSP151125267Z
Language:
English
Publisher:
National Library of Serbia
Publication Date:
2017
detail.hit.zdb_id:
2169819-3
SSG:
15,3
