In:
Journal of Investigative Medicine, SAGE Publications, Vol. 61, No. 6 ( 2013-08), p. 950-955
Abstract:
Following the initial discovery of a natriuretic and diuretic peptide factor present in atrial myocardial tissue homogenates, subsequent elucidation of the natriuretic peptide (NP) family has led to substantial advances in the understanding of the autocrine, paracrine, and endocrine regulation of the cardiovascular system. Furthermore, with the development of assays for the measurement of the NPs, these important biomarkers have gone from being regarded as biological mediators of the cardiovascular system to now represent important clinical tools for the diagnostic and prognostic evaluation of patients with heart failure and may have potential as a therapeutic target in this setting as well. An historical perspective on the NPs from bench to bedside translation will be discussed.
Type of Medium:
Online Resource
ISSN:
1081-5589
,
1708-8267
DOI:
10.2310/JIM.0b013e3182946b69
Language:
English
Publisher:
SAGE Publications
Publication Date:
2013
