In:
Diabetes Care, American Diabetes Association, Vol. 33, No. 2 ( 2010-02-01), p. 408-410
Abstract:
Fetuin-A is an inhibitor of vascular calcification and a mediator of insulin resistance. This study evaluated the association of plasma fetuin-A and peripheral arterial disease (PAD). RESEARCH DESIGN AND METHODS A total of 738 individuals with type 2 diabetes (mean age 58.7 years, 37.1% female) without known cardiovascular or kidney disease were included in this cross-sectional analysis. RESULTS Subjects with PAD had a significantly lower fetuin-A (264.3 vs. 293.4 ng/dl, P & lt; 0.001). In multivariable analysis, a 1-SD decrease in fetuin-A increased the odds of PAD (odds ratio 1.6, P = 0.02). Subgroup analysis revealed an increased odds even in subjects with glomerular filtration rate & gt;80 (odds ratio 1.9, P = 0.05) or high-sensitivity C-reactive protein & lt;3 mg/dl (odds ratio 2.7, P = 0.002). CONCLUSIONS Lower circulating fetuin-A is associated with PAD in type 2 diabetes beyond traditional and novel cardiovascular risk factors. Our findings suggest a potentially unique role for fetuin-A deficiency as a biomarker of PAD in patients with type 2 diabetes.
Type of Medium:
Online Resource
ISSN:
0149-5992
,
1935-5548
Language:
English
Publisher:
American Diabetes Association
Publication Date:
2010
detail.hit.zdb_id:
1490520-6