In:
American Journal of Veterinary Research, American Veterinary Medical Association (AVMA), Vol. 61, No. 6 ( 2000-06-01), p. 714-718
Abstract:
Objective —To correlate substance P content of synovial fluid with prostaglandin E 2 content, radiographic evidence of joint abnormality, and anatomic location of the joint for normal and osteoarthritic joints of horses. Sample Population —Synovial fluid from 46 normal joints in 21 horses and 16 osteoarthritic joints in 10 horses. Procedure —Normal and osteoarthritic joints were identified by clinical and radiographic examination, by response to nerve blocks, during scintigraphy or surgery, or by clinicopathologic evaluation. Substance P and prostaglandin E 2 contents of synovial fluid were determined by radioimmunoassay. Radiographs of joints were assigned a numeric score reflecting severity of lesions. Joints were assigned a numeric score reflecting anatomic location. Results —Median concentrations of substance P and prostaglandin E2 were significantly increased in osteoarthritic joints, compared with normal joints. A significant correlation was found between concentrations of substance P and prostaglandin E 2 in synovial fluid, but a correlation was not detected between substance P concentration in synovial fluid and anatomic location of the joint or between radiographic scores of osteoarthritic joints and concentrations of substance P or prostaglandin E 2 . Conclusions and Clinical Relevance —A correlation existed between concentrations of substance P and prostaglandin E 2 in synovial fluid obtained from normal and osteoarthritic joints. However, content of substance P in synovial fluid cannot be predicted by the radiographic appearance of the joint or its anatomic location. Substance P and prostaglandin E 2 may share an important and related role in the etiopathogenesis of osteoarthritis, lending credence to the importance of neurogenic inflammation in horses. ( Am J Vet Res 2000;61: 714–718)
Type of Medium:
Online Resource
ISSN:
0002-9645
DOI:
10.2460/ajvr.2000.61.714
Language:
Unknown
Publisher:
American Veterinary Medical Association (AVMA)
Publication Date:
2000
detail.hit.zdb_id:
2056942-7
SSG:
22
