In:
American Journal of Veterinary Research, American Veterinary Medical Association (AVMA), Vol. 62, No. 4 ( 2001-04-01), p. 581-587
Kurzfassung:
Objective —To evaluate effects of intra-articular and
extracapsular reconstruction of the cranial cruciate ligament (CCL) on metabolism of articular cartilage as
reflected by concentrations of chondroitin sulfate epitopes 3B3 and 7D4 in synovial fluid. Animals —13 adult dogs. Procedure —Each dog underwent unilateral CCL transection
(CCLT). One month after CCLT, sham CCL reconstruction (3 dogs), intra-articular CCL reconstruction
(5), or extracapsular CCL reconstruction (5) was performed. Synovial fluid was collected by direct
arthrocentesis from CCLT and contralateral stifle joints immediately before (time 0) and 1, 3, and 5
months after CCLT. Fluid was examined for concentrations of 3B3 and 7D4 epitopes and total sulfated
glycosaminoglycan (GAG) content. Results —Concentrations of 3B3, 7D4, and GAG,
3B3:GAG, or 7D4:GAG in CCLT joints did not differ significantly among treatment groups nor in the ratios of
these variables in CCLT joints to contralateral joints at 3 months. In a longitudinal analysis, concentrations of
3B3 and 7D4, 3B3:GAG, and 7D4:GAG in CCLT joints in all groups changed significantly with time, but we
did not detect time X group interactions. Conclusion and Clinical Relevance —Transection
of CCL resulted in significant perturbation in articular cartilage metabolism as reflected by alterations in
concentrations of 3B3 and 7D4 in synovial fluid. These changes over time were not significantly influenced
by method of CCL reconstruction. We did not find evidence that surgical stabilization of CCL-deficient joints
by intra-articular or extracapsular techniques had any effect on preventing alterations in composition of synovial
fluid that have been associated with secondary osteoarthritis. ( Am J Vet Res 2001;62:581–587)
Materialart:
Online-Ressource
ISSN:
0002-9645
DOI:
10.2460/ajvr.2001.62.581
Sprache:
Unbekannt
Verlag:
American Veterinary Medical Association (AVMA)
Publikationsdatum:
2001
ZDB Id:
2056942-7
SSG:
22
