In:
Journal of Research in Physics, Walter de Gruyter GmbH, Vol. 36, No. 1 ( 2012-01-1), p. 53-62
Abstract:
Fluorescence excitation-emission spectroscopy was used to investigate specimens of normal and malignant human breast tissues. Measurements were performed in two spectral regions: in the excitation range from 335nm to 400nm and emission range from 430nm to 625 nm, and in the excitation range from 400nm to 470nm and emission range from 500nm to 640 nm. It was found that fluorescence spectra are composed mainly of the emissions of extracellular proteins and that the differences in the intensity of their emissions reveal the changes in the tissue structure and morphology. These differences could be best observed in the emission spectra excited with 370 nm, 425nm and 455nm radiation. Statistical analysis revealed several spectral subregions that exhibited extremely significant statistical difference between normal and malignant breast tissues. The origin of these differences was elaborated, and prospects for optical diagnostics of breast cancer was discussed.
Type of Medium:
Online Resource
ISSN:
2217-933X
DOI:
10.2478/v10242-012-0013-z
Language:
Unknown
Publisher:
Walter de Gruyter GmbH
Publication Date:
2012
detail.hit.zdb_id:
2676891-4
