In:
CHIMIA, Swiss Chemical Society, Vol. 58, No. 3 ( 2004-03-01), p. 123-
Abstract:
The inhibition of the cholesteryl ester transfer protein (CETP) provides a method for the elevation of the high density lipoprotein cholesterol (HDL-C) level, i.e. the 'good' cholesterol. The expected anti-atherogenic effect
of this approach is independent of the proven benefits of lowering the low density lipoprotein cholesterol (LDL-C) level, i.e. the 'bad' cholesterol. A medicinal chemistry project is presented starting from the first screening hit to the second generation development candidate. The structure–activity relationship, the syntheses and the role of fluorine during optimization, as well as the biological activities are discussed.
Type of Medium:
Online Resource
ISSN:
2673-2424
,
0009-4293
DOI:
10.2533/000942904777678082
Language:
Unknown
Publisher:
Swiss Chemical Society
Publication Date:
2004
detail.hit.zdb_id:
2179192-2