In:
Life Science Alliance, Life Science Alliance, LLC, Vol. 3, No. 8 ( 2020-08), p. e202000640-
Abstract:
HIV and EBV are human pathogens that cause a considerable burden to worldwide health. In combination, these viruses are linked to AIDS-associated lymphomas. We found that EBV, which transforms B cells, renders them susceptible to HIV-1 infection in a CXCR4 and CD4-dependent manner in vitro and that CXCR4-tropic HIV-1 integrates into the genome of these B cells with the same molecular profile as in autologous CD4 + T cells. In addition, we established a humanized mouse model to investigate the in vivo interactions of EBV and HIV-1 upon coinfection. The respective mice that reconstitute human immune system components upon transplantation with CD34 + human hematopoietic progenitor cells could recapitulate aspects of EBV and HIV immunobiology observed in dual-infected patients. Upon coinfection of humanized mice, EBV/HIV dual-infected B cells could be detected, but were susceptible to CD8 + T-cell–mediated immune control.
Type of Medium:
Online Resource
ISSN:
2575-1077
DOI:
10.26508/lsa.202000640
Language:
English
Publisher:
Life Science Alliance, LLC
Publication Date:
2020
detail.hit.zdb_id:
2948687-7
