In:
Comparative Medicine, American Association for Laboratory Animal Science, Vol. 70, No. 6 ( 2020-12-01), p. 520-525
Kurzfassung:
Nonbronchoscopic bronchoalveolar lavage (NB-BAL) is a minimally invasive diagnostic and research tool used to sample the cells of lower airways and alveoli without using a bronchoscope. Our study compared NB-BAL and bronchoscopic bronchoalveolar lavage (B-BAL) in terms of costs, cell
yields, and the number of post-procedural complications in macaques. We also analyzed procedure times, BAL fluid volume yields, and vital signs in a subset of animals that underwent NB-BAL. Compared with the B-BAL technique, NB-BAL was less expensive to perform, with fewer complications, fewer animals requiring temporary or permanent cessation of BALs, and higher cell yields per mL of recovered saline. The average procedure time for NB-BAL was 6.8 ± 1.6 min, and the average NB-BAL lavage volume yield was 76 ± 9%. We found no significant differences in respiration rate
before, during, or after NB-BAL but did find significant differences in heart rate and oxygen saturation (SpO 2 ). This study demonstrates that NB-BAL is a simple, cost-effective, and safe alternative to B-BAL that results in higher cell yields per mL, improved animal welfare, and
fewer missed time points, and thus constitutes a refinement over the B-BAL in macaques.
Materialart:
Online-Ressource
ISSN:
1532-0820
DOI:
10.30802/AALAS-CM-99-990066
Sprache:
Englisch
Verlag:
American Association for Laboratory Animal Science
Publikationsdatum:
2020
ZDB Id:
2053069-9
SSG:
22