In:
Experimental and Clinical Gastroenterology, LLC Global Media Technology, , No. 7 ( 2022-10-07), p. 38-44
Kurzfassung:
Rpose of the study. To study the relationship between fatal cardiovascular events and non-alcoholic fatty liver disease (NAFLD) among the population of the Irkutsk region. Materials and methods. The study was conducted on the basis of the Irkutsk Regional Bureau of Forensic Medicine. The object of the study was the medical documentation - “The autopsy report”. Results. To study the possible relationship, a retrospective analysis of the results of 2220 autopsies performed over 3 years was carried out: 2010-2012. in the pathological department. Signs of non-alcoholic fatty liver disease according to morphological studies were identified in 271 cases. Conclusions. 1.In patients with NAFLD, body weight can be equally normal and increased. Among patients with increased body weight, women predominate. 2. In men, there is a moderate positive correlation between the thickness of the subcutaneous fat and the mass of the liver; in women, this connection was not found. 3. Morphologically, coarse fatty degeneration of the liver is more common. 4. Every second patient with NAFLD (49%) died of CVD. Among the dead, men reliably predominate. The dominant cause of death is cardiovascular disease (AMI), followed by impaired cerebral circulation. Mortality peaks in middle and old age. 5. The total mortality from CVD for 3 years according to the pathology department of the Irkutsk Regional Clinical Hospital was 423 cases (19%) (n = 2220). Among all deaths from CVD, one in three (133 cases (31.4%)) had fatty changes in the liver. Conclusion: the results obtained confirm the hypothesis of the existence of a relationship between NAFLD and CVD, which is based on disorders of fat metabolism that develop as a result of impaired normal function of hepatocytes against the background of their fatty lesions. In accordance with this statement, it is necessary to think about considering NAFLD as a component of metabolic syndrome.
Materialart:
Online-Ressource
ISSN:
1682-8658
DOI:
10.31146/1682-8658-ecg-203-7-38-44
Sprache:
Unbekannt
Verlag:
LLC Global Media Technology
Publikationsdatum:
2022
