In:
Oral Rehabilitation and Dentistry, Science Repository OU
Abstract:
Dentoalveolar abscess, a localized accumulation of pus in the alveolar bone, can produce significant changes
in alveolar bone proper that may be resulted by dental caries, trauma or pulpitis causing alveolar bone resorption or even loss. Unfortunately, it can extend vertically toward the apex of the tooth. Additionally,
a periapical abscess may form in the alveolar bone adjacent to the apex of the tooth. Interestingly, many bacterial products can stimulate osteoclast formation and bone resorption of periapical tissues. This review
displayed drugs that can affect bone resorption that classified as (1) Osteoclast inhibitors such as: bisphosphonates, gene therapeutic (Cathepsin K) estrogens, selective estrogen receptor modulators
(SERMs), calcitonin monoclonal antibodies such as denosumab and (2) Osteoclast activators such as DMPPYT, nuclear factor-Kappa B (RANK) signaling and adrenomedullin.
Type of Medium:
Online Resource
DOI:
10.31487/j.ORD.2019.01.05
Language:
Unknown
Publisher:
Science Repository OU
Publication Date:
2019
