In:
Journal of Food Bioactives, International Society for Nutraceuticals & Functional Foods (ISNFF), Vol. 24 ( 2023-12-31)
Kurzfassung:
Photoaging is the premature aging of skin caused by long-term exposure to ultraviolet radiation. The skin mucus of Andrias davidianus has anti-photoaging activity, but its active ingredients and mechanisms are not clear. In this study, we first investigated the photoprotective effect of enzymatic hydrolysates from Andrias davidianus mucus (AD-APRO) on UVA-irradiated responses in human skin fibroblasts (HSF) cells and mice. AD-APRO hindered the UVA induced activation of reactive oxygen species (ROS) and increased the activity of antioxidase in HSF cells. Furthermore, topical application of AD-APRO ameliorated skin photoaging in a mouse model by suppressing oxidative stress. CAMP and Peptide Ranker, two online tools, were used to predict the active peptides of AD-APRO against photoaging. The active peptides of AD-APRO were predicted to be KDACCNLVLHFNPRF, NLVLHFNPRF, FEWKP, and CNLVLHFNPRF. These results provide a basis for the study of the photoprotective effect of AD-APRO and suggest that it can be potentially used as an agent against UVA-induced skin photoaging in humans.
Materialart:
Online-Ressource
ISSN:
2637-8779
,
2637-8752
DOI:
10.31665/JFB.2023.18365
Sprache:
Unbekannt
Verlag:
International Society for Nutraceuticals & Functional Foods (ISNFF)
Publikationsdatum:
2023
ZDB Id:
3005768-1
