In:
Journal of Chemical Research, SAGE Publications, Vol. 42, No. 9 ( 2018-09), p. 471-473
Abstract:
An improved and efficient method for the synthesis of panobinostat was developed. The commercially available starting material 4-(chloromethyl)benzaldehyde was converted to ( E)-methyl 3-[4-(chloromethyl)phenyl]acrylate via the Wittig–Horner reaction and was then directly condensed with 2-(2-methyl-1 H-indol-3-yl)ethanamine to afford the key intermediate ( E)-methyl 3-[4-({[2-(2-methyl-1 H-indol-3-yl)ethyl] amino}methyl)phenyl]acrylate in a one-pot synthesis reactor. Subsequently a nucleophilic substitution reaction was carried out smoothly to generate the desired compound. The key intermediate and target compound were characterised by HRMS, 1 H NMR and 13 C NMR. This procedure is operationally simple and would be more suitable for industrial production.
Type of Medium:
Online Resource
ISSN:
1747-5198
,
2047-6507
DOI:
10.3184/174751918X15357309308931
Language:
English
Publisher:
SAGE Publications
Publication Date:
2018
detail.hit.zdb_id:
3010810-X