In:
Journal of Alzheimer's Disease, IOS Press, Vol. 83, No. 3 ( 2021-09-28), p. 1033-1038
Kurzfassung:
The consistency of cerebrospinal fluid amyloid-β (Aβ)42/40 ratio and Aβ42 has not been assessed in the AT(N) classification system. We analyzed the classification changes of the dichotomized amyloid status (A+/A–) in 363 patients tested for Alzheimer’s disease biomarkers after Aβ42 was superseded by the Aβ42/40 ratio. The consistency of Aβ42 and the Aβ42/40 ratio was very low. Notably, the proportions of “false” A+T–patients were considerable (74–91%) and corresponded mostly to patients not clinically diagnosed with Alzheimer’s disease. Our results suggest that the interchangeability of Aβ42/40 ratio and Aβ42 is limited for classifying patients in clinical setting using the AT(N) scheme.
Materialart:
Online-Ressource
ISSN:
1387-2877
,
1875-8908
Sprache:
Unbekannt
Verlag:
IOS Press
Publikationsdatum:
2021
ZDB Id:
2070772-1
