In:
Macedonian Pharmaceutical Bulletin, Macedonian Pharmaceutical Association, Vol. 62, No. 1 ( 2016), p. 77-84
Abstract:
Caffeine is odorless, bitter taste substance which can be naturally found in coffee, cocoa, tea leaves, and is intentionally added in food and pharmaceutical products. It can also be found in surface water in small concentrations where is often used as an excellent indicator of human waste. The aim of the work is determination of caffeine content in food, beverages, analgesics and surface water using solidphase extraction followed by high-performance liquid chromatography (HPLC). Caffeine content was determined in 12 commercial tea and coffee products, non-alcoholic energy drinks and food, 5 combined preparations of analgesics and the Danube samples collected from
7 representative locations. The results showed that caffeine content in food ranged 5,6-158 mg/100 g, tea samples 24,71-30,81 mg/100 ml, coffee samples 1328-3594 mg/100 g, energy drinks 9,69-30,79 mg/100 ml and in the Danube samples 15,91-306,12 ng/l. Caffeine content in combined commercial formulations of non-narcotic analgesics of all brands did meet specifications. The data suggested that the proposed HPLC method can be used for routine determination and control of caffeine content in different matrices.
Type of Medium:
Online Resource
ISSN:
1857-8969
,
1409-8695
DOI:
10.33320/maced.pharm.bull.2016.62.01
DOI:
10.33320/MacedPharmBull
DOI:
10.33320/maced.pharm.bull.2016.62.01.007
Language:
English
Publisher:
Macedonian Pharmaceutical Association
Publication Date:
2016
