In:
Karaelmas İş Sağlığı ve Güvenliği Dergisi, Bulent Evcevit University, Vol. 5, No. 2 ( 2021-08-31), p. 147-161
Abstract:
Manganese (Mn), a heavy metal commonly used in industry, is a trace element required for many enzymatic processes that drive biological functions. However, excess exposure to Mn leads to toxicity. Its toxic effects on the central nervous system are important. The typical manifestation of Mn over exposure is parkinsonism, which may be challenging to differentiate it from more common idiopathic Parkinson's disease. In addition to occupational and environmental exposure to Mn, other potential etiologies causing Mn toxicity include systemic diseases, total parenteral nutrition and some drugs. In this review, we evaluated occupational and environmental exposure of Mn, its pathophysiology and clinical characteristics. We have highlighted the impact of Mn exposure at the workplace and emphasize the necessity of a detailed occupational and environmental history to ensure that a toxicity is not misdiagnosed as a neurodegenerative disease. In the absence of a comprehensive treatment, early diagnosis and timely initiation of preventive measures are the keys to managing Mn toxic effects.
Type of Medium:
Online Resource
ISSN:
2636-7602
DOI:
10.33720/kisgd.951525
Language:
Unknown
Publisher:
Bulent Evcevit University
Publication Date:
2021
