In:
Frontiers in Cell and Developmental Biology, Frontiers Media SA, Vol. 10 ( 2022-9-16)
Kurzfassung:
The mitochondrial unfolded protein response (UPR mt ) is a molecular mechanism that maintains mitochondrial proteostasis under stress and is closely related to various metabolic diseases, such as type 2 diabetes (T2D). Similarly, the unfolded protein response of the endoplasmic reticulum (UPR ER ) is responsible for maintaining proteomic stability in the endoplasmic reticulum (ER). Since the mitochondria and endoplasmic reticulum are the primary centers of energy metabolism and protein synthesis in cells, respectively, a synergistic mechanism must exist between UPR mt and UPR ER to cooperatively resist stresses such as hyperglycemia in T2D. Increasing evidence suggests that the protein kinase RNA (PKR)-like endoplasmic reticulum kinase (PERK) signaling pathway is likely an important node for coordinating UPR mt and UPR ER . The PERK pathway is activated in both UPR mt and UPR ER , and its downstream molecules perform important functions. In this review, we discuss the mechanisms of UPR mt , UPR ER and their crosstalk in T2D.
Materialart:
Online-Ressource
ISSN:
2296-634X
DOI:
10.3389/fcell.2022.974083
Sprache:
Unbekannt
Verlag:
Frontiers Media SA
Publikationsdatum:
2022
ZDB Id:
2737824-X
