In:
Frontiers in Cardiovascular Medicine, Frontiers Media SA, Vol. 9 ( 2022-3-17)
Abstract:
Asthma and cardiovascular disease (CVD) share many risk factors. Previous meta-analyses indicated that asthma is associated with an increased risk of CVD and all-cause mortality, but these studies were limited by unstandardized search strategies and the number of articles included. Objective We sought to systematically synthesize evidence investigating the impact of asthma on all-cause mortality and CVD morbidity and mortality. Methods We searched in PubMed and EMBASE for observational cohort studies (inception dates to November 10, 2021) that had both asthma groups and control groups. We also manually searched the reference lists of correlative articles to include other eligible studies. Data for associations between asthma and all-cause mortality and CVD morbidity and mortality were needed. Results We summarized the findings from 30 cohort studies comprising 4,157,823 participants. Asthma patients had increased CVD morbidity [relative risk (RR) = 1.28, 95% confidence interval (CI) = 1.16–1.40] and increased CVD mortality (RR = 1.25, 95% CI = 1.14–1.38). Asthma patients also had increased risk of all-cause mortality (RR = 1.38, 95% CI = 1.07–1.77). In subgroup analyses, female asthma patients had a higher risk of CVD morbidity and all-cause mortality than male asthma patients, and late-onset asthma patients had a higher risk of CVD morbidity than early-onset asthma patients. Conclusion Asthma patients have increased risk of all-cause mortality and CVD morbidity and mortality. This information reminds clinicians to be aware of the risk of CVD and all-cause mortality in asthma patients. Systematic Review Registration http://www.crd.york.ac.uk/PROSPERO/ , PROSPERO, identifier: CRD 42021290082.
Type of Medium:
Online Resource
ISSN:
2297-055X
DOI:
10.3389/fcvm.2022.861798
DOI:
10.3389/fcvm.2022.861798.s001
DOI:
10.3389/fcvm.2022.861798.s002
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10.3389/fcvm.2022.861798.s003
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10.3389/fcvm.2022.861798.s004
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10.3389/fcvm.2022.861798.s005
DOI:
10.3389/fcvm.2022.861798.s006
DOI:
10.3389/fcvm.2022.861798.s007
DOI:
10.3389/fcvm.2022.861798.s008
DOI:
10.3389/fcvm.2022.861798.s009
DOI:
10.3389/fcvm.2022.861798.s010
DOI:
10.3389/fcvm.2022.861798.s011
DOI:
10.3389/fcvm.2022.861798.s012
DOI:
10.3389/fcvm.2022.861798.s013
DOI:
10.3389/fcvm.2022.861798.s014
DOI:
10.3389/fcvm.2022.861798.s015
DOI:
10.3389/fcvm.2022.861798.s016
Language:
Unknown
Publisher:
Frontiers Media SA
Publication Date:
2022
detail.hit.zdb_id:
2781496-8
