In:
Frontiers in Endocrinology, Frontiers Media SA, Vol. 13 ( 2022-5-3)
Kurzfassung:
Type 2 diabetes is a risk factor for dementia. We investigated whether serum levels of soluble triggering receptor expressed on myeloid cell 2 (sTREM2), a soluble form of the cell surface receptor TREM2, were predictive of cognitive impairment in type 2 diabetes without obesity. Methods A total of 166 Japanese patients with type 2 diabetes without obesity were followed-up for 2 years. We measured clinical parameters, assessed cognitive function using the mini-mental state examination (MMSE), quantified and divided serum sTREM2 levels into quartiles, and examined the longitudinal associations. Results During the follow-up, HbA 1c levels were elevated in 98 patients and decreased in 68 patients. In the HbA 1c -elevated group, higher sTREM2 levels at baseline showed a significant association with a greater tendency for reduction in MMSE scores ( P for trend = 0.015), whereas they were not significantly associated with other examined parameters. In the HbA 1c -decreased group, there was no significant association between sTREM2 levels at baseline and changes in MMSE scores, but higher sTREM2 levels at baseline were significantly associated with a greater tendency for reduction in waist circumference ( P for trend = 0.027), homeostasis model assessment of insulin resistance ( P for trend = 0.039), and sTREM2 levels ( P for trend = 0.023). Conclusions Glycemic control is suggested to be important in preventing cognitive impairment in patients with type 2 diabetes without obesity. Higher serum sTREM2 levels would be a predictive marker for cognitive impairment in inadequately controlled type 2 diabetes without obesity.
Materialart:
Online-Ressource
ISSN:
1664-2392
DOI:
10.3389/fendo.2022.880148
DOI:
10.3389/fendo.2022.880148.s001
Sprache:
Unbekannt
Verlag:
Frontiers Media SA
Publikationsdatum:
2022
ZDB Id:
2592084-4
