In:
Frontiers in Endocrinology, Frontiers Media SA, Vol. 13 ( 2022-6-20)
Abstract:
Systemic inflammation and insulin resistance (IR) are closely related in patients with cancer. However, there is no relevant indicator that combines inflammation and IR to predict patient prognosis. Therefore, this study aimed to develop and validate a novel inflammation- and IR-related marker in patients with cancer. Methods The total cohort of this study included 5221 patients with cancer, and the training and validation cohorts were randomized in a 7:3 ratio. C-reactive protein (CRP) and fasting triglyceride glucose (TyG) were used to reflect patients’ inflammation and IR status, respectively. The CRP-TyG index (CTI) was composed of CRP and TyG. The concordance (C)-index, receiver operator characteristic (ROC) curve, and calibration curve reflected the prognostic predictive power of CTI. Univariate and multivariate survival analyses predicted the prognostic value of CTI in patients with cancer. Results The C-indices of CTI in patients with cancer were 0.636, 0.617, and 0.631 in the total, training, and validation cohorts, respectively. The 1-, 3-, and 5-year ROC and calibration curves showed that CTI had a good predictive ability of survival in patients with cancer. Meanwhile, patients with high CTI had a worse prognosis compared to patients with low CTI (total cohort: hazard ratio [HR] = 1.46, 95% confidence interval [95% CI] = 1.33–1.59; training cohort: HR = 1.36, 95% CI = 1.22–1.52; validation cohort: HR = 1.73, 95% CI = 1.47–2.04]. Conclusion The CTI is a useful prognostic indicator of poor prognosis and a promising tool for treatment strategy decision-making in patients with cancer.
Type of Medium:
Online Resource
ISSN:
1664-2392
DOI:
10.3389/fendo.2022.905266
DOI:
10.3389/fendo.2022.905266.s001
DOI:
10.3389/fendo.2022.905266.s002
DOI:
10.3389/fendo.2022.905266.s003
DOI:
10.3389/fendo.2022.905266.s004
DOI:
10.3389/fendo.2022.905266.s005
DOI:
10.3389/fendo.2022.905266.s006
DOI:
10.3389/fendo.2022.905266.s007
DOI:
10.3389/fendo.2022.905266.s008
DOI:
10.3389/fendo.2022.905266.s009
DOI:
10.3389/fendo.2022.905266.s010
DOI:
10.3389/fendo.2022.905266.s011
Language:
Unknown
Publisher:
Frontiers Media SA
Publication Date:
2022
detail.hit.zdb_id:
2592084-4