In:
Frontiers in Genetics, Frontiers Media SA, Vol. 12 ( 2021-3-18)
Kurzfassung:
Enhancer RNAs, a type of long non-coding RNAs (lncRNAs), play a critical role in the occurrence and development of glioma. RNA-seq data from 161 glioblastoma multiforme (GBM) samples were acquired from The Cancer Genome Atlas database. Then, 70 eRNAs were identified as prognosis-related genes, which had significant relations with overall survival (log-rank test, p & lt; 0.05). AC003092.1 was demonstrated as an immune-related eRNA by functional enrichment analysis. We divided samples into two groups based on AC003092.1 expression: AC003092.1 High (AC003092.1_H) and AC003092.1 Low (AC003092.1_L) and systematically analyzed the influence of AC003092.1 on the immune microenvironment by single-sample gene-set enrichment analysis and CIBERSORTx. We quantified AC003092.1 and TFPI2 levels in 11 high-grade gliomas, 5 low-grade gliomas, and 7 GBM cell lines. Our study indicates that AC003092.1 is related to glioma-immunosuppressive microenvironment, and these results offer innovative sights into GBM immune therapy.
Materialart:
Online-Ressource
ISSN:
1664-8021
DOI:
10.3389/fgene.2021.633812
DOI:
10.3389/fgene.2021.633812.s001
DOI:
10.3389/fgene.2021.633812.s002
DOI:
10.3389/fgene.2021.633812.s003
DOI:
10.3389/fgene.2021.633812.s004
DOI:
10.3389/fgene.2021.633812.s005
Sprache:
Unbekannt
Verlag:
Frontiers Media SA
Publikationsdatum:
2021
ZDB Id:
2606823-0