In:
Frontiers in Immunology, Frontiers Media SA, Vol. 13 ( 2022-6-13)
Kurzfassung:
High-risk human papillomavirus (hrHPV) infection has been associated with a higher probability of progression to cervical cancer. However, several extensive studies have reported that the presence of hrHPV can lead to a better prognosis, but the mechanism of how this occurs is unclear. In this study, microbiological analysis was used to identify HPV infection as a factor for the prognosis of patients with cervical squamous cell carcinoma (CSCC). Comparing the interactions of HPV + and HPV - malignant cells with immune cells as well as the trajectory of malignant cells either with or without HPV, we found that most of the HPV + cells are well differentiated while HPV - cells appear to be hypo-fractionated. Using transcriptomic and immunostaining data, we validated a set of unfavourable molecules in the HPV - CSCC cells, including KRT16, ITGB1, CXCR1, VEGFA, CRCT1 and TNFRSF10B/DR5. This study provides a basis for the development of a rational post-operative follow-up programme and the development of an appropriate treatment plan for patients with cervical cancer.
Materialart:
Online-Ressource
ISSN:
1664-3224
DOI:
10.3389/fimmu.2022.907599
DOI:
10.3389/fimmu.2022.907599.s001
DOI:
10.3389/fimmu.2022.907599.s002
DOI:
10.3389/fimmu.2022.907599.s003
DOI:
10.3389/fimmu.2022.907599.s004
DOI:
10.3389/fimmu.2022.907599.s005
DOI:
10.3389/fimmu.2022.907599.s006
DOI:
10.3389/fimmu.2022.907599.s007
DOI:
10.3389/fimmu.2022.907599.s008
DOI:
10.3389/fimmu.2022.907599.s009
DOI:
10.3389/fimmu.2022.907599.s010
Sprache:
Unbekannt
Verlag:
Frontiers Media SA
Publikationsdatum:
2022
ZDB Id:
2606827-8
