In:
Frontiers in Immunology, Frontiers Media SA, Vol. 13 ( 2022-6-15)
Abstract:
T cell responses are considered critical for the in vivo control of HIV, but the contribution of different T cell subsets to this control remains unclear. Using a boosted flow cytometric approach that is able to differentiate CD4 + and CD8 + T cell Th1/Tc1, Th2/Tc2, Th17/Tc17, Treg and Tfh/Tfc-like HIV-specific T cell populations, we identified CD8 + Tfc responses that were related to HIV plasma viral loads and associated with rate of antibody isotype class switching to IgG. This favorable balance towards IgG responses positively correlated with increased virus neutralization, higher avidity of neutralizing antibodies and more potent antibody-dependent cell cytotoxicity (ADCC) in PBMCs from HIV controllers compared to non-controllers. Our results identified the CD8 + Tfc-like T-cell response as a component of effective virus control which could possibly be exploited therapeutically.
Type of Medium:
Online Resource
ISSN:
1664-3224
DOI:
10.3389/fimmu.2022.928039
DOI:
10.3389/fimmu.2022.928039.s001
DOI:
10.3389/fimmu.2022.928039.s002
DOI:
10.3389/fimmu.2022.928039.s003
DOI:
10.3389/fimmu.2022.928039.s004
DOI:
10.3389/fimmu.2022.928039.s005
DOI:
10.3389/fimmu.2022.928039.s006
DOI:
10.3389/fimmu.2022.928039.s007
DOI:
10.3389/fimmu.2022.928039.s008
DOI:
10.3389/fimmu.2022.928039.s009
Language:
Unknown
Publisher:
Frontiers Media SA
Publication Date:
2022
detail.hit.zdb_id:
2606827-8