In:
Frontiers in Immunology, Frontiers Media SA, Vol. 14 ( 2023-6-12)
Abstract:
Idiopathic inflammatory myopathy (IIM) is a heterogeneous group of autoimmune diseases with various clinical manifestations, treatment responses, and prognoses. According to the clinical manifestations and presence of different myositis-specific autoantibodies (MSAs), IIM is classified into several major subgroups, including PM, DM, IBM, ASS, IMNM, and CADM. However, the pathogenic mechanisms of these subgroups remain unclear and need to be investigated. Here, we applied MALDI-TOF-MS to examine the serum metabolome of 144 patients with IIM and analyze differentially expressed metabolites among IIM subgroups or MSA groups. The results showed that the DM subgroup had lower activation of the steroid hormone biosynthesis pathway, while the non-MDA5 MSA group had higher activation of the arachidonic acid metabolism pathway. Our study may provide some insights into the heterogeneous mechanisms of IIM subgroups, potential biomarkers, and management of IIM.
Type of Medium:
Online Resource
ISSN:
1664-3224
DOI:
10.3389/fimmu.2023.1188257
DOI:
10.3389/fimmu.2023.1188257.s001
DOI:
10.3389/fimmu.2023.1188257.s002
DOI:
10.3389/fimmu.2023.1188257.s003
DOI:
10.3389/fimmu.2023.1188257.s004
DOI:
10.3389/fimmu.2023.1188257.s005
DOI:
10.3389/fimmu.2023.1188257.s006
Language:
Unknown
Publisher:
Frontiers Media SA
Publication Date:
2023
detail.hit.zdb_id:
2606827-8
