In:
Frontiers in Medicine, Frontiers Media SA, Vol. 8 ( 2021-2-15)
Abstract:
The emergence of the novel human coronavirus, SARS-CoV-2, causes a global COVID-19 (coronavirus disease 2019) pandemic. Here, we have characterized and compared viral populations of SARS-CoV-2 among COVID-19 patients within and across households. Our work showed an active viral replication activity in the human respiratory tract and the co-existence of genetically distinct viruses within the same host. The inter-host comparison among viral populations further revealed a narrow transmission bottleneck between patients from the same households, suggesting a dominated role of stochastic dynamics in both inter-host and intra-host evolutions.
Type of Medium:
Online Resource
ISSN:
2296-858X
DOI:
10.3389/fmed.2021.585358
DOI:
10.3389/fmed.2021.585358.s001
DOI:
10.3389/fmed.2021.585358.s002
DOI:
10.3389/fmed.2021.585358.s003
DOI:
10.3389/fmed.2021.585358.s004
DOI:
10.3389/fmed.2021.585358.s005
DOI:
10.3389/fmed.2021.585358.s006
Language:
Unknown
Publisher:
Frontiers Media SA
Publication Date:
2021
detail.hit.zdb_id:
2775999-4