In:
Frontiers in Neurology, Frontiers Media SA, Vol. 13 ( 2022-3-28)
Abstract:
The aim of this study is to investigate the safety and efficiency of a Jrecan ® flow restoration system, a novel thrombectomy device, in an arterial thromboembolic occlusion model of Beagle dogs. Methods A total of 12 Beagle dogs with acute thromboembolism were randomized to receive mechanical thrombectomy with either Jrecan ® flow restoration device or Trevo TM PROVUE Device (2:1). The efficacy and safety of the two devices, including recanalization rate, the presence of distal embolism, vasospasm, vessel perforation, and vessel injuries were evaluated through DSA and microscopic examination. Result A 100% recanalization rate (mTICI 2b/3) was achieved in both groups. Endothelial and subendothelial injuries occurred in all target vessels. Focal disruption of internal elastic lamina was observed in 4 cases. The mean vessel injury score of the Jrecan ® group was 1.16 ± 0.48, significantly lower than that of the Trevo TM group (1.54 ± 0.8) ( P & lt; 0.001). Conclusion The Jrecan ® and Trevo TM devices demonstrated an equally high recanalization rate in Beagle dogs with acute thromboembolism. However, histological findings revealed that the Jrecan ® stent seemed to be safer than the Trevo TM device during clot retrieval, which might be related to a more appropriate radial force provided by the Jrecan ® stent that resulted from its wider cell design.
Type of Medium:
Online Resource
ISSN:
1664-2295
DOI:
10.3389/fneur.2022.858670
Language:
Unknown
Publisher:
Frontiers Media SA
Publication Date:
2022
detail.hit.zdb_id:
2564214-5
