In:
Frontiers in Neuroscience, Frontiers Media SA, Vol. 16 ( 2023-1-6)
Abstract:
The gamma subunit of calcium/calmodulin-dependent protein kinase 2 (CAMK2G) is expressed throughout the brain and is associated with neurodevelopmental disorders. Research on the role of CAMK2G is limited and attributes different functions to specific cell types. Methods To further expand on the role of CAMK2G in brain functioning, we performed extensive phenotypic characterization of a Camk2g knockout mouse. Results We found different CAMK2G isoforms that show a distinct spatial expression pattern in the brain. Additionally, based on our behavioral characterization, we conclude that CAMK2G plays a minor role in hippocampus-dependent learning and synaptic plasticity. Rather, we show that CAMK2G is required for motor function and that the loss of CAMK2G results in impaired nest-building and marble burying behavior, which are innate behaviors that are associated with impaired neurodevelopment. Discussion Taken together, our results provide evidence for a unique function of this specific CAMK2 isozyme in the brain and further support the role of CAMK2G in neurodevelopment.
Type of Medium:
Online Resource
ISSN:
1662-453X
DOI:
10.3389/fnins.2022.1086994
DOI:
10.3389/fnins.2022.1086994.s001
DOI:
10.3389/fnins.2022.1086994.s002
DOI:
10.3389/fnins.2022.1086994.s003
DOI:
10.3389/fnins.2022.1086994.s004
DOI:
10.3389/fnins.2022.1086994.s005
Language:
Unknown
Publisher:
Frontiers Media SA
Publication Date:
2023
detail.hit.zdb_id:
2411902-7