In:
Frontiers in Physiology, Frontiers Media SA, Vol. 12 ( 2021-10-14)
Abstract:
Background: In addition to the cardiovascular and renal systems, the gastrointestinal tract also contains angiotensin ATR 1a , ATR 1b , and ATR 2 . We previously observed that the 2Kidney-1Clip hypertension model elicits physical exercise and gastrointestinal dysmotility, which is prevented by renin-angiotensin system blockers. Here, we investigate the effect of physical exercise on inflammation, stress biomarkers, and angiotensin II receptors in the duodenum of 2K1C rats. Methods: Arterial hypertension was induced by the 2K1C surgical model. The rats were allocated in Sham, 2K1C, or 2K1C+Exercise groups. One week after surgery, they were submitted to a physical exercise protocol (running 5x/week, 60min/day). Next, we assessed their intestinal contractility, cytokine levels (TNF-α, IL-1β, and IL-6), oxidative stress levels (MPO, GSH, MDA, and SOD), and the gene expression of angiotensin receptors (ATR 1A , ATR 1B , and ATR 2 ). Results: In comparison with the Sham group, the 2K1C arterial hypertension decreased ( p & lt;0.05) the intestinal contractility. In comparison with 2K1C, the 2K1C+Exercise group exhibited lower ( p & lt;0.05) MPO activity (22.04±5.90 vs. 78.95±18.09 UMPO/mg tissue) and higher ( p & lt;0.05) GSH concentrations in intestinal tissues (67.63±7.85 vs. 31.85±5.90mg NPSH/mg tissue). The 2K1C+Exercise group showed lower ( p & lt;0.05) cytokine levels in the intestine than 2K1C rats. In comparison with the Sham group, the 2K1C+Exercise rats showed higher ( p & lt;0.05) gene expression of ATR 2 in the duodenum. Conclusion: 2K-1C hypertension elicits an oxidative stress and inflammation process in the duodenum. Physical exercise modulates the expression twice as much of ATR2 receptors, suggesting possible anti-inflammatory and antioxidant effects induced by exercise.
Type of Medium:
Online Resource
ISSN:
1664-042X
DOI:
10.3389/fphys.2021.734038
Language:
Unknown
Publisher:
Frontiers Media SA
Publication Date:
2021
detail.hit.zdb_id:
2564217-0
