In:
Frontiers in Public Health, Frontiers Media SA, Vol. 10 ( 2022-5-12)
Kurzfassung:
Evidence of the association between maternal sulfur dioxide (SO 2 ) exposure and the risk of omphalocele is limited and equivocal. We aimed to assess the aforementioned topic during the first trimester of pregnancy. A population-based case-control study was carried out in infants consisting of 292 cases of omphalocele and 7,950 healthy infant controls. Exposure to SO 2 , particulate matter with aerodynamic diameters ≤ 10 μm, and nitrogen dioxide was assessed by averaging the concentration from all stations in the mother's residential city. SO 2 exposure was categorized into three groups, with the lowest tertile defined as the reference category. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using multivariable logistic regression models. Higher SO 2 exposure during the first trimester was significantly associated with omphalocele risk [per standard deviation (42 ug/m 3 ) increment: OR = 1.39, 95% CI = 1.22–1.65]. When focusing on shorter exposure windows, similar positive associations were observed for SO 2 exposure in the first and third months of pregnancy. In addition, compared with the lowest tertile, high SO 2 exposure in the second month of pregnancy increased the risk of omphalocele (OR = 2.80, 95% CI = 1.61–4.97). Maternal exposure to SO 2 during the first trimester may increase the risk of omphalocele in offspring.
Materialart:
Online-Ressource
ISSN:
2296-2565
DOI:
10.3389/fpubh.2022.821905
DOI:
10.3389/fpubh.2022.821905.s001
DOI:
10.3389/fpubh.2022.821905.s002
Sprache:
Unbekannt
Verlag:
Frontiers Media SA
Publikationsdatum:
2022
ZDB Id:
2711781-9
