In:
Biology, MDPI AG, Vol. 10, No. 5 ( 2021-05-08), p. 417-
Abstract:
MicroRNAs (miRNAs) are small non-coding RNAs. They can regulate the expression of their target genes, and thus, their dysregulation significantly contributes to the development of cancer. Growing evidence suggests that miRNAs could be used as cancer biomarkers. As an oncogenic miRNA, the roles of miR-21 as a diagnostic and prognostic biomarker, and its therapeutic applications have been extensively studied. In this review, the roles of miR-21 are first demonstrated via its different molecular networks. Then, a comprehensive review on the potential targets and the current applications as a diagnostic and prognostic cancer biomarker and the therapeutic roles of miR-21 in six different cancers in the digestive system is provided. Lastly, a brief discussion on the challenges for the use of miR-21 as a therapeutic tool for these cancers is added.
Type of Medium:
Online Resource
ISSN:
2079-7737
DOI:
10.3390/biology10050417
Language:
English
Publisher:
MDPI AG
Publication Date:
2021
detail.hit.zdb_id:
2661517-4