In:
Diseases, MDPI AG, Vol. 6, No. 4 ( 2018-10-20), p. 95-
Abstract:
The cytokine profile during acute chikungunya infection that predicts future chronic arthritis has not yet been investigated. We conducted a nested case-control study comparing serum cytokine concentrations during acute chikungunya infection in cases (n = 121) that reported the presence of chronic joint pain versus age- and gender-matched controls (n = 121) who reported recovery at 20 months post infection. We observed that a robust cytokine response during acute infection was correlated with a decreased incidence of chronic joint pain and that low TNFα, IL-13, IL-2, and IL-4 during acute infection was predictive of chronic joint pain. These data suggest that a robust cytokine response is necessary for viral clearance and cytokines that are related to immune tolerance during acute infection may be protective for chronic arthritis pathogenesis.
Type of Medium:
Online Resource
ISSN:
2079-9721
DOI:
10.3390/diseases6040095
Language:
English
Publisher:
MDPI AG
Publication Date:
2018
detail.hit.zdb_id:
2720869-2
