In:
International Journal of Molecular Sciences, MDPI AG, Vol. 16, No. 4 ( 2015-04-03), p. 7587-7594
Abstract:
Scutellarin (1) has been used for the treatment of angina pectoris, cerebral infarction and coronary heart disease with a large market share in China. Pharmacokinetic studies on scutellarin showed that scutellarin (1) is readily converted into its metabolites in vivo. In this paper, a new and practical synthetic method for the synthesis of 6-O-methyl-scutellarein (3) (one metabolite of scutellarin in vivo) is reported. The benzyl bromide was firstly used to selectively replace the acetyl group at C-7 in 7, and was then used to protect the hydroxy groups at C-4' in 10, 6-O-methyl-scutellarein (3) is obtained in high yield through these methods.
Type of Medium:
Online Resource
ISSN:
1422-0067
DOI:
10.3390/ijms16047587
Language:
English
Publisher:
MDPI AG
Publication Date:
2015
detail.hit.zdb_id:
2019364-6
SSG:
12