In:
International Journal of Molecular Sciences, MDPI AG, Vol. 20, No. 6 ( 2019-03-25), p. 1484-
Abstract:
The protozoan Trypanosoma brucei, responsible for animal and human trypanosomiasis, has a family of major surface proteases (MSPs) and phospholipase-C (PLC), both involved in some mechanisms of virulence during mammalian infections. During parasitism in the mammalian host, this protozoan is exclusively extracellular and presents a robust mechanism of antigenic variation that allows the persistence of infection. There has been incredible progress in our understanding of how variable surface glycoproteins (VSGs) are organised and expressed, and how expression is switched, particularly through recombination. The objective of this manuscript is to create a reflection about the mechanisms of antigenic variation in T. brucei, more specifically, in the process of variable surface glycoprotein (VSG) release. We firstly explore the mechanism of VSG release as a potential pathway and target for the development of anti-T. brucei drugs.
Type of Medium:
Online Resource
ISSN:
1422-0067
DOI:
10.3390/ijms20061484
Language:
English
Publisher:
MDPI AG
Publication Date:
2019
detail.hit.zdb_id:
2019364-6
SSG:
12
