In:
Journal of Clinical Medicine, MDPI AG, Vol. 11, No. 17 ( 2022-08-30), p. 5106-
Abstract:
Metabolic abnormalities, such as preexisting diabetes or hyperglycemia or hypoglycemia during hospitalization aggravated the severity of COVID-19. We evaluated whether diabetes history, hyperglycemia before and during extracorporeal membrane oxygenation (ECMO) support, and hypoglycemia were risk factors for mortality in patients with COVID-19. This study included data on 195 patients with COVID-19, who were aged ≥19 years and were treated with ECMO. The proportion of patients with diabetes history among nonsurvivors was higher than that among survivors. Univariate Cox regression analysis showed that in-hospital mortality after ECMO support was associated with diabetes history, renal replacement therapy (RRT), and body mass index (BMI) 〈 18.5 kg/m2. Glucose at admission 〉 200 mg/dL and glucose levels before ventilator 〉 200 mg/dL were not associated with in-hospital mortality. However, glucose levels before ECMO 〉 200 mg/dL and minimal glucose levels during hospitalization 〈 70 mg/dL were associated with in-hospital mortality. Multivariable Cox regression analysis showed that glucose 〉 200 mg/dL before ECMO and minimal glucose 〈 70 mg/dL during hospitalization remained risk factors for in-hospital mortality after adjustment for age, BMI, and RRT. In conclusion, glucose 〉 200 mg/dL before ECMO and minimal glucose level 〈 70 mg/dL during hospitalization were risk factors for in-hospital mortality among COVID-19 patients who underwent ECMO.
Type of Medium:
Online Resource
ISSN:
2077-0383
Language:
English
Publisher:
MDPI AG
Publication Date:
2022
detail.hit.zdb_id:
2662592-1