In:
Journal of Renal Injury Prevention, Maad Rayan Publishing Company, Vol. 10, No. 3 ( 2020-05-29), p. e20-e20
Abstract:
Introduction: N-terminal pro–B-type natriuretic peptide (NT-proBNP) is a novel marker of cardiac disease and heart failure; both are in patients with diabetes and chronic kidney disease. Objectives: This study aimed to investigate the NT-proBNP and adverse outcome in patients with diabetes complicated by chronic kidney disease (CKD). Patients and Methods: We measured the serum levels of NT-proBNP. The association of this novel marker with re-hospitalization and mortality rate were prospectively compared among the studied groups. Results: Among 120 patients, baseline NT-proBNP at the time of admission was significantly elevated in patients with CKD ( P = 0.001). Levels of NT-proBNP were significantly elevated in patients with diabetes and CKD than those with CKD alone ( P = 0.04) at the end of follow-up. Higher proBNP levels significantly correlated with decreased glomerular filtration rate (GFR) and higher serum creatinine levels ( P = 0.03, P 〈 0.001, respectively). In addition, increased mortality was noticed in those patients. Conclusion: NT-proBNP levels have prognostic implication in the setting of CKD, diabetes mellitus and heart failure. Adverse outcomes are; a higher rate of need for dialysis, re-hospitalization and increased mortality which are correlated with levels of NT-proBNP.
Type of Medium:
Online Resource
ISSN:
2345-2781
DOI:
10.34172/jrip.2021.20
Language:
English
Publisher:
Maad Rayan Publishing Company
Publication Date:
2020
detail.hit.zdb_id:
2747305-3
