In:
Toxicological Review, Federal Scientific Center for Hygiene F.F.Erisman, , No. 1 ( 2019-02-28), p. 23-28
Abstract:
Thearticlepresentstheresultsofastudyoftheneurotoxicologicalprofileofanew5-HT2A-antagonist(compoundI) using the method of multi-test observation by «S. Irwin». The test parameters were evaluated in parallel groups, receiving the compound in doses beginning with the average effective dose (ED50) and with a multiple increase of 2, 5, 7.5 and 10 times. The study revealed that the neurotoxicological properties of compound I are characterized by dose-dependent activity. It has been shown that neurotoxicological changes in the behavior of the animals did not occur with the administration of compound I at average effective dose of 10 mg / kg and doses, exceeding the effective by 2 and 5 times; the animals welfare corresponds to that of the control group. The most significant effects by the administration of the studied compound developed in high doses, exceeding the effective by 7.5 and 10 times. The limits of the minimum toxic dose (TDmin) for compound I by oral administration has been found to be 50 mg / kg 〈 TDmin≤75 mg / kg.
Type of Medium:
Online Resource
ISSN:
0869-7922
DOI:
10.36946/0869-7922-2019-1
DOI:
10.36946/0869-7922-2019-1-23-28
Language:
Unknown
Publisher:
Federal Scientific Center for Hygiene F.F.Erisman
Publication Date:
2019