In:
Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics, Computers, Materials and Continua (Tech Science Press), Vol. 26, No. 9 ( 2018-10-17), p. 1391-1399
Abstract:
The direct roles of miR-139-3p on hepatocellular carcinoma (HCC) cell growth and metastasis remain poorly understood. We attempted to demonstrate the regulatory role of miR-139-3p in HCC progression and its underlying mechanisms. Here we showed that miR-139-3p expression was significantly
reduced in the HCC tissues compared to paratumor tissues. Exogenous overexpression of miR-139-3p inhibited the migration and invasion of HCC cells, whereas downregulation of miR-139-3p was able to induce HCC HepG2 and SNU-449 cell migration and invasion. In addition, miR-139-3p inhibited HCC growth and lung metastasis in an in vivo mouse model, which is mainly regulated by annexin A2 receptor (ANXA2R). Finally, we identified that the expression of miR-139-3p was inversely correlated with ANXA2R expression in human HCC tissue. All these results demonstrated that miR-139-3p inhibited
the metastasis process in HCC by downregulating ANXA2R expression.
Type of Medium:
Online Resource
ISSN:
0965-0407
DOI:
10.3727/096504018X15178798885361
Language:
English
Publisher:
Computers, Materials and Continua (Tech Science Press)
Publication Date:
2018
detail.hit.zdb_id:
1114699-0
detail.hit.zdb_id:
2044620-2
