In:
Revista de Chimie, Revista de Chimie SRL, Vol. 70, No. 9 ( 2019-10-15), p. 3250-3253
Abstract:
Gastrointestinal stromal tumors (GIST�sare the most common mesenchymal neoplasms of the alimentary tract. Angiogenesis is an essential condition in the growth and development of tumors, especially in the case of GISTs due to their particular behavior. The aggressive behavior depends on the size and site of the tumor in close relationship with the intratumoral vascular development. The purpose of this study is to investigate, using immunohistochemical stainings, the types of intratumoral vessels in GIST�s, knowing the interrelation between the tumor angiogenesis and the response to the targeted antivascular therapy, influencing directly the prognosis. In our research, in all 37 cases the most numerous vessels were the immature and intermediate ones, signaling an increased angiogenic activity. The perivascular cell free vessels are the most sensitive at antivascular therapy with tyrosine kinase receptor inhibitors, providing a good response and prognosis to the treatment. Immature vessels evaluation especially, could be a an important sign in assessment of the effectiveness of antivascular therapy in GIST.
Type of Medium:
Online Resource
ISSN:
0034-7752
,
2668-8212
DOI:
10.37358/RC.19.9.7528
Language:
English
Publisher:
Revista de Chimie SRL
Publication Date:
2019
detail.hit.zdb_id:
2488208-2