In:
Beilstein Journal of Organic Chemistry, Beilstein Institut, Vol. 11 ( 2015-12-22), p. 2689-2695
Abstract:
Cyclic N 1 -pentylinosine monophosphate (cpIMP), a novel simplified inosine derivative of cyclic ADP-ribose (cADPR) in which the N 1 -pentyl chain and the monophosphate group replace the northern ribose and the pyrophosphate moieties, respectively, was synthesized. The role played by the position of the phosphate group in the key cyclization step, which consists in the formation of a phosphodiester bond, was thoroughly investigated. We have also examined the influence of the phosphate bridge on the ability of cpIMP to mobilize Ca 2+ in PC12 neuronal cells in comparison with the pyrophosphate bridge present in the cyclic N 1 -pentylinosine diphosphate analogue (cpIDP) previously synthesized in our laboratories. The preliminary biological tests indicated that cpIMP and cpIDP induce a rapid increase of intracellular Ca 2+ concentration in PC12 neuronal cells.
Type of Medium:
Online Resource
ISSN:
1860-5397
Language:
English
Publisher:
Beilstein Institut
Publication Date:
2015
detail.hit.zdb_id:
2192461-2