In:
Pharmacia, Pensoft Publishers, Vol. 69, No. 3 ( 2022-08-24), p. 801-808
Abstract:
The present work was carried out to assess the value of adding water insoluble polymer to meloxicam amorphous solid formulation (ASD). Meloxicam was mixed with polyvinylpyrrolidone (PVP) (1:1 ratio) as a binary mixture and with PVP and ethyl cellulose (1:1:1 ratio) as a ternary mixture. Solvent evaporation method was used to prepare ASD formulations. The differential scanning calorimetry, powder X-Ray diffraction, Cambridge Structural Database and in-vitro dissolution were performed to assess the formulas. The results showed that the addition of insoluble polymer could prevent the recrystallization process during ASD formation. However, the binary mixture showed higher drug release percentage than the ternary mixture. Therefore, a rational amount of insoluble polymer could be considered to control recrystallization and manipulate drug release from ASD formulations.
Type of Medium:
Online Resource
ISSN:
2603-557X
,
0428-0296
DOI:
10.3897/pharmacia.69.e86744
DOI:
10.3897/pharmacia.69.e86744.figure1
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10.3897/pharmacia.69.e86744.figure2
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10.3897/pharmacia.69.e86744.figure3
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10.3897/pharmacia.69.e86744.figure5
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10.3897/pharmacia.69.e86744.figure4
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10.3897/pharmacia.69.e86744.figure6
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10.3897/pharmacia.69.e86744.figure7
DOI:
10.3897/pharmacia.69.e86744.figure8
Language:
Unknown
Publisher:
Pensoft Publishers
Publication Date:
2022
detail.hit.zdb_id:
3010005-7
SSG:
15,3