In:
Advanced Materials Research, Trans Tech Publications, Ltd., Vol. 518-523 ( 2012-05-14), p. 3917-3920
Abstract:
In this study, benzaldehyde was reacted with benzoin condensation, oxidation and cyclization reaction to product phenytoin sodium under the supersonic wave radiation. In the condensation reaction, non-toxic vitamin B1 was used as a reactor instead of highly toxic cyanide on pH=9 at 70 oC. After that, FeCl3 • 6H2O was used as oxidant instead of concentrated nitric acid under the mild conditions. The results were that the yield of phenytoin sodium was up to 56.8%. There were many advantages in this improved synthesis method such as shorter reaction time, higher product purity, lower environmental pollution and higher product yield.
Type of Medium:
Online Resource
ISSN:
1662-8985
DOI:
10.4028/www.scientific.net/AMR.518-523
DOI:
10.4028/www.scientific.net/AMR.518-523.3917
Language:
Unknown
Publisher:
Trans Tech Publications, Ltd.
Publication Date:
2012
detail.hit.zdb_id:
2265002-7