In:
Key Engineering Materials, Trans Tech Publications, Ltd., Vol. 342-343 ( 2007-7), p. 533-536
Abstract:
The purpose of the present study was to develop a polymer film loaded with drug to
effectively prevent pin tract infection. It was found that the polymer, poly ethylene-co-vinyl acetate blended with tetrahydrofuran, showed better flexibility and deformability than the other polymers:
poly caprolactone18 and poly caprolactone44. Polymer films, poly ethylene-co-vinyl acetate, were divided into five testing groups dependent on the loading concentration of rifampici (5, 10, 15, and
20 wt %). The surface morphology of polymer films was examined by a scanning electron microscopy. It was found that the concentration of drug was a main factor to determine the
roughness of the film. Considering the roughness of polymer films, 5 wt % of rifampicin might be the maximum concentration for further applications. Hence, the antibiotic drug-loaded polymer
films were manufactured by mixing poly(ethylene-co-vinylacetate) and tetrahydrofuran with rifampicin(antibiotic drug). The film cast was designed as a shape of disk (inner Ø5mm and outer
Ø20mm) to be suitable for pins for external fixation in orhtopaedics. The drug-loaded polymer solvent, the amount of 0.6cc, was molded into the disk-shaped film and dried into a airtight box at
15°C for 24 hrs. The drug release characteristics(1, 2, 3, 4 and 5 wt%) were examined as a function of soaking time in phosphate buffered saline (PBS, 10 ml) using an enzyme-linked immunosorbent
assay. Rifampicin was linearly released for first 100 hrs(~4 days) for all antibiotic drug-loaded polymer films. Afterward, the drug was released at a slower pace as a function of square root of
time until 1000 hrs (~40 days). This slow drug release can be explained by their hydrophobic characteristics of poly ethylene-co-vinyl acetate and rifampicin. The antibiotic drug-loaded polymer
film can be intrinsically able to prevent the bacteria adhesion by wrapping the pin track area, and perform active and effective infection-resistant by a sustained antibiotic-release.
Type of Medium:
Online Resource
ISSN:
1662-9795
DOI:
10.4028/www.scientific.net/KEM.342-343
DOI:
10.4028/www.scientific.net/KEM.342-343.533
Language:
Unknown
Publisher:
Trans Tech Publications, Ltd.
Publication Date:
2007
detail.hit.zdb_id:
2073306-9
