In:
Key Engineering Materials, Trans Tech Publications, Ltd., Vol. 368-372 ( 2008-2), p. 1224-1226
Abstract:
The microstructure of scaffold was one of key factors for tissue engineering. Porous
polycaprolactone (PCL) scaffolds were fabricated by combination of porogen-leaching and freeze-drying process. Ice particulates were used as porogen material, and PCL solutions in chloroform were mixed
with ice particulates for 5minuture at zero temperature. Then the mixture was freezed in liquid nitrogen, and porous scaffold was prepared by freeze - drying finally. The microstructure and properties of the scaffolds were investigated. Porous structure of the scaffolds showed that good 3D microstructure and no
porogen remained in the scaffold; pore size and porosity were determined by the size and mass fraction of ice particulates. The results demonstrated that the Scaffolds possessed open and interconnected pores
with sizes ranging from several μm to more than 300μm and porosities of 50~80%.
Type of Medium:
Online Resource
ISSN:
1662-9795
DOI:
10.4028/www.scientific.net/KEM.368-372
DOI:
10.4028/www.scientific.net/KEM.368-372.1224
Language:
Unknown
Publisher:
Trans Tech Publications, Ltd.
Publication Date:
2008
detail.hit.zdb_id:
2073306-9