In:
The Journal of Immunology, The American Association of Immunologists, Vol. 182, No. 5 ( 2009-03-01), p. 3032-3038
Abstract:
The Foxp3-expressing subset of regulatory CD4+ T cells have defined Ag specificity and play essential roles in maintaining peripheral tolerance by suppressing the activation of self-reactive T cells. Similarly, during chronic infection, pathogen-specific Foxp3-expressing CD4+ T cells expand and actively suppress pathogen-specific effector T cells. Herein, we used MHC class II tetramers and Foxp3gfp knockin mice to track the kinetics and magnitude whereby pathogen-specific Foxp3+CD4+ and Foxp3−CD4+ cells are primed and expand after acute infection with recombinant Listeria monocytogenes (Lm) expressing the non-“self”-Ag 2W1S52–68. We demonstrate that Lm infection selectively primes proliferation, expansion, and subsequent contraction of Lm-specific Foxp3− effector CD4+ cells, while the numbers of Lm-specific Foxp3+CD4+ regulatory cells remain essentially unchanged. In sharp contrast, purified 2W1S52–68 peptide primes coordinated expansion of both Foxp3+ regulatory and Foxp3− effector T cells with the same Ag specificity. Taken together, these results indicate selective priming and expansion of Foxp3− CD4 T cells is a distinguishing feature for acute bacterial infection.
Type of Medium:
Online Resource
ISSN:
0022-1767
,
1550-6606
DOI:
10.4049/jimmunol.0803402
Language:
English
Publisher:
The American Association of Immunologists
Publication Date:
2009
detail.hit.zdb_id:
1475085-5
