In:
The Journal of Immunology, The American Association of Immunologists, Vol. 109, No. 5 ( 1972-11-01), p. 1149-1151
Abstract:
The classification of lymphocytes into bursal derived (B)2 and thymic derived (T) subpopulations has been a significant advance in our understanding of lymphocyte biology. A variety of immune functions have been attributed to each of these subpopulations, while other functions depend on a cooperation between both cell types (1). It has been suggested that lymphokines, the biologically active substances produced in vitro by activated lymphocytes (2, 3) are produced by T lymphocytes (2). However, little definitive experimental evidence to substantiate this conclusion has been reported. The agammaglobulinemic (aγ) chicken has been shown to be largely depleted of B cells (4, 5) and represents an excellent model in which to investigate the contributions of B and T cells to various aspects of the immune response (6). In the present investigation we have adapted a recently described assay of mononuclear leukocyte (MNL) chemotaxis (7) to study lymphokine production by mitogen-stimulated normal and aγ chicken spleen cells.
Type of Medium:
Online Resource
ISSN:
0022-1767
,
1550-6606
DOI:
10.4049/jimmunol.109.5.1149
Language:
English
Publisher:
The American Association of Immunologists
Publication Date:
1972
detail.hit.zdb_id:
1475085-5
