In:
The Journal of Immunology, The American Association of Immunologists, Vol. 168, No. 12 ( 2002-06-15), p. 6253-6262
Kurzfassung:
MHC-I-restricted CTL responses of H-2d (Ld+ or Ld−) and F1 H-2dxb mice to hepatitis B surface Ag (HBsAg) are primed by either DNA vaccines or HBsAg particles. The Dd/S201–209 and Kd/S199–208 epitopes are generated by processing endogenous HBsAg; the Kb/S208–215 epitope is generated by processing exogenous HBsAg; and the Ld/S28–39 epitope is generated by exogenous as well as endogenous processing of HBsAg. DNA vaccination primed high numbers of CTL specific for the Ld/S28–39 HBsAg epitope, low numbers of CTL specific for the Dd/S201–209 or Kd/S199–208 HBsAg epitopes in BALB/c mice, and high numbers of Dd/S201–209- and Kd/S199–208-specific CTL in congenic H-2d/Ld− dm2 mice. In F1dxb mice, the Kd-, Dd-, and Kb-restricted CTL responses to HBsAg were strikingly suppressed in the presence but efficiently elicited in the absence of Ld/S28–39-specific CTL. Once primed, the Kd- and Dd-restricted CTL responses to HBsAg were resistant to suppression by immunodominant Ld/S28–39-specific CTL. The Ld-restricted immunodominant CTL reactivity to HBsAg can thus suppress priming to multiple alternative epitopes of HBsAg, independent of the processing pathway that generates the epitope, of the background of the mouse strain used, and of the presence/absence of different allelic variants of the K and D MHC class I molecules.
Materialart:
Online-Ressource
ISSN:
0022-1767
,
1550-6606
DOI:
10.4049/jimmunol.168.12.6253
Sprache:
Englisch
Verlag:
The American Association of Immunologists
Publikationsdatum:
2002
ZDB Id:
1475085-5
