In:
The Journal of Immunology, The American Association of Immunologists, Vol. 199, No. 1 ( 2017-07-01), p. 119-128
Abstract:
Innate immunity activation by viral RNA–primed retinoid acid inducible gene-I (Rig-I) in CD4+ T cells antagonizes TGFβ signaling to suppress the differentiation of regulatory T cells (Tregs). However, how viral RNA–unliganded Rig-I (apo–Rig-I) modulates Treg generation remains unclear. In this article, we show that, in the absence of viral infection, Treg differentiation of Rig-I−/− CD4+ T cells was compromised, in the presence of increased generation of Th17 cells and overactivation of Stat3, a critical regulator tilting the Treg/Th17 cell balance. Mechanistically, apo–Rig-I physically associates with Stat3, thereby inhibiting Jak1’s association with Stat3 while facilitating Shp2’s association to inhibit p-Stat3 levels. Interestingly, inhibition of Stat3 ameliorates the Treg/Th17 imbalance and the colitis observed in Rig-I−/− mice. Collectively, these results uncover an independent functional contribution of the apo–Rig-I/Stat3 interaction in the maintenance of Treg/Th17 cell balance.
Type of Medium:
Online Resource
ISSN:
0022-1767
,
1550-6606
DOI:
10.4049/jimmunol.1700366
Language:
English
Publisher:
The American Association of Immunologists
Publication Date:
2017
detail.hit.zdb_id:
1475085-5
