In:
The Journal of Immunology, The American Association of Immunologists, Vol. 173, No. 12 ( 2004-12-15), p. 7259-7268
Abstract:
Naturally occurring CD4+ regulatory T cells are generally identified through their expression of CD25. However, in several experimental systems considerable Treg activity has been observed in the CD4+CD25− fraction. Upon adoptive transfer, the expression of CD25 in donor-derived cells is not stable, with CD4+CD25+ cells appearing in CD4+CD25− T cell-injected animals and vice versa. We show in this study that CD25+ cells arising from donor CD25− cells upon homeostatic proliferation in recipient mice express markers of freshly isolated Treg cells, display an anergic state, and suppress the proliferation of other cells in vitro. The maintenance of CD25 expression by CD4+CD25+ cells depends on IL-2 secreted by cotransferred CD4+CD25− or by Ag-stimulated T cells in peripheral lymphoid organs.
Type of Medium:
Online Resource
ISSN:
0022-1767
,
1550-6606
DOI:
10.4049/jimmunol.173.12.7259
Language:
English
Publisher:
The American Association of Immunologists
Publication Date:
2004
detail.hit.zdb_id:
1475085-5
