In:
The Journal of Immunology, The American Association of Immunologists, Vol. 188, No. 1_Supplement ( 2012-05-01), p. 123.5-123.5
Kurzfassung:
A major role for the Slamf6 gene in the pathogenesis of lupus-related autoimmunity has been revealed by the analysis of a number of congenic mutant mouse strains. Importantly, upon introduction of one copy of a BAC transgene expressing the protein isoform Slamf6-H1 markedly ameliorates T cell-dependent lupus in the Sle1b mouse, which lacks H1. Here we report that a PD-1+ subset of memory CD4+ T cells dramatically expands in Sle1b mice, but not in Sle1b mice, which express Slamf6-H1. Further analysis showed that this PD-1+ population mainly consists of CXCR5+ T follicular helper cells the expansion of which is prevented by Slamf6-H1 as well as by the absence of the adapter SAP. Surprisingly, these T follicular helper cells express the cytokine osteopontin, which is known to drive polyclonal B cell proliferation. As the human osteopontin gene have been linked to the development of SLE, the outcomes of the present studies could suggest novel therapeutic modalities for SLE patients.
Materialart:
Online-Ressource
ISSN:
0022-1767
,
1550-6606
DOI:
10.4049/jimmunol.188.Supp.123.5
Sprache:
Englisch
Verlag:
The American Association of Immunologists
Publikationsdatum:
2012
ZDB Id:
1475085-5
