In:
The Journal of Immunology, The American Association of Immunologists, Vol. 198, No. 1_Supplement ( 2017-05-01), p. 152.8-152.8
Abstract:
IL-2 promotes FoxP3+ regulatory T (Treg) cell responses, but inhibits the differentiation of T follicular helper (Tfh) cells. However, it is not clear how IL-2 affects T follicular regulatory (Tfr) cells, a cell type with properties of both Treg and Tfh cells. Here we show that IL-2 prevents, rather than promotes, the development of Tfr cells. Using an influenza infection model, we found that Tfr cells were barely detectable at the peak of the infection, but accumulated as the immune response resolved. High levels of IL-2 at the peak of the infection promoted the expression of Blimp-1 in Treg cells, which suppressed Bcl6 expression and thereby precluded Tfr cell development. However, as IL-2 levels declined some CD25+ Treg cells down-regulated CD25, up-regulated Bcl6 and differentiated into Tfr cells, which prevented the accumulation of self-reactive antibody-secreting cells. Thus, unlike its effects on conventional Treg cells, IL-2 inhibits Tfr cell responses.
Type of Medium:
Online Resource
ISSN:
0022-1767
,
1550-6606
DOI:
10.4049/jimmunol.198.Supp.152.8
Language:
English
Publisher:
The American Association of Immunologists
Publication Date:
2017
detail.hit.zdb_id:
1475085-5
